Article

Anesthetics fragment hippocampal network activity, alter spine dynamics and affect memory consolidation

2020-06-06

Abstract excerpt

<h4>ABSTRACT</h4> General anesthesia is characterized by reversible loss of consciousness accompanied by transient amnesia. Yet, long-term memory impairment is an undesirable side-effect. How different types of general anesthetics (GAs) affect the hippocampus, a brain region central to memory formation and consolidation, is poorly understood. Using extracellular recordings, chronic 2-photon imaging and behavioral...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7c7ccbfb-f659-5459-8ce4-24c31be76ca1
DOI: 10.1101/2020.06.05.135905

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Anesthetics fragment hippocampal network activity, alter spine dynamics and affect memory consolidationDOI 10.1101/2020.06.05.135905Read

Prolonged anesthesia alters brain synaptic architectureSemantic proximity Read

Subcortical recruitment dissociates isoflurane emergence from distinct wakeful states in miceSemantic proximity Read

Mapping general anesthesia states based on electro-encephalogram transition phasesSemantic proximity Read

Mapping Large-scale Spatiotemporal Dynamics of Synaptic Plasticity and LTP for Memory Encoding in the Hippocampal NetworkSemantic proximity Read

How can I run sleep and anesthesia studies with intracranial EEG?Semantic proximity Read

Ketamine can produce oscillatory dynamics by engaging mechanisms dependent on the kinetics of NMDA receptorsSemantic proximity Read

Cortico-thalamic excitatory-inhibitory dynamics generates <i>α</i> -wave transient patterns encoding anesthetic brain statesSemantic proximity Read

Unique spatiotemporal fMRI dynamics in the awake mouse brainSemantic proximity Read

Astrocytic Foxo1 regulates hippocampal spinogenesis and synaptic plasticity to enhance fear memorySemantic proximity Read

Ca <sup>2+</sup> signaling in astrocytes is sleep-wake state specific and modulates sleepSemantic proximity Read

Restoring the loss of consciousness under sevoflurane anesthesia in states of anxiety and depression by potently activating serotonergic pathways in brainSemantic proximity Read

Simultaneous brain-wide single-cell recording resolves spatiotemporal memory architectureSemantic proximity Read