Article

Multi-environment phenotyping of <i>C. elegans</i> for robust evaluation of physical performance

2020-08-17

Abstract excerpt

<h4>ABSTRACT</h4> Determining the physical performance of humans using several measures is essential to evaluating the severity of diseases, understanding the role of environmental factors, and developing therapeutic interventions. Development of analogous measures of physical performance in model organisms can help in identifying conserved signaling pathways and prioritizing drug candidates. In this study, we pr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e4290a47-8c24-5506-bce7-5f61cc009ff7
DOI: 10.1101/2020.08.17.253583

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Multi-environment phenotyping of <i>C. elegans</i> for robust evaluation of physical performanceDOI 10.1101/2020.08.17.253583Read

Muscle strength deficiency and mitochondrial dysfunction in a muscular dystrophy model of Caenorhabditis elegans and its functional response to drugsSemantic proximity Read

Comparative Analysis of Experimental Methods to Quantify Animal Activity in Caenorhabditis elegans Models of Mitochondrial Disease.Semantic proximity Read

Investigating the correlation of muscle function tests and sarcomere organization in <i>C. elegans</i>Semantic proximity Read

Quantitative Analysis of Drug Efficacy on <i>C. elegans</i> Models for Neuromuscular DiseasesSemantic proximity Read

The burrowing behavior of the nematode <i>Caenorhabditis elegans</i>: a new assay for the study of neuromuscular disordersSemantic proximity Read

Pluronic gel-based burrowing assay for rapid assessment of neuromuscular health in <i>C. elegans</i>Semantic proximity Read

High-throughput behavioural phenotyping of 25 <i>C. elegans</i> disease models including patient-specific mutationsSemantic proximity Read

Exercise exacerbates decline in the musculature of an animal model of Duchenne muscular dystrophySemantic proximity Read

PRO-FitS: a novel phenotypic assay to identify enhancers of proteostasis in <i>C. elegans</i>Semantic proximity Read

Pluronic gel-based burrowing assay for rapid assessment of neuromuscular health in C. elegans.Semantic proximity Read

Systematic creation and phenotyping of Mendelian disease models in <i>C. elegans</i> : towards large-scale drug repurposingSemantic proximity Read

Mechanical stress through growth on stiffer substrates impacts animal health and longevity in <i>C. elegans</i>Semantic proximity Read