Article

Systematic creation and phenotyping of Mendelian disease models in <i>C. elegans</i> : towards large-scale drug repurposing

2023-08-28

Abstract excerpt

There are thousands of Mendelian diseases with more being discovered weekly and the majority have no approved treatments. To address this need, we require scalable approaches that are relatively inexpensive compared to traditional drug development. In the absence of a validated drug target, phenotypic screening in model organisms provides a route for identifying candidate treatments. Success requires a screenable...

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Literature Corpus work: 97376b33-b301-5e92-9bea-4235af9043c0
DOI: 10.1101/2023.08.25.554786

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