Article

Flotillin-dependent lipid-raft microdomains are required for functional phagolysosomes against fungal infections

2019-04-12

Abstract excerpt

<h4>SUMMARY</h4> Lipid rafts form signaling platforms on biological membranes with incompletely characterized role in immune response to infection. Here we report that lipid raft microdomains are essential components of the phagolysosomal membrane of macrophages. Genetic deletion of the lipidraft chaperons flotillin-1 and flotillin-2 demonstrate that the assembly of both major defense complexes vATPase and NADPH...

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Literature Corpus work: e40f2e5f-0266-50b6-8f7b-f8df9ad24ee5
DOI: 10.1101/606939

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