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Article

Potential role of p53 deregulation in modulating immune responses in human malignancies: A paradigm to develop immunotherapy.

Cancer letters - 28 Apr 2024

Chauhan Shivi, Jaiswal Shivani, Jakhmola Vibhuti, Singh Bhavana, Bhattacharya Sujata, Garg Manoj, Sengupta Shinjinee

Abstract excerpt

The crucial role played by the oncogenic expression of TP53, stemming from mutation or amyloid formation, in various human malignancies has been extensively studied over the past two decades. Interestingly, the potential role of TP53 as a crucial player in modulating immune responses has provided new insight into the field of cancer biology. The loss of p53's transcriptional functions and/or the acquisition of...

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Identifiers

PMID: 38408603
DOI: 10.1016/j.canlet.2024.216766
PMCID: PMC7615729

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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