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Article

Lentiviral vector integration sites in human NOD/SCID repopulating cells

8 Sept 2006

Abstract excerpt

BACKGROUND: Recent observations of insertional mutagenesis in preclinical and clinical settings emphasize the relevance of investigating comprehensively the spectrum of integration sites targeted by specific vectors. METHODS: We followed the engraftment of lentivirally transduced human cord blood (CB) progenitor cells after transplantation into NOD/SCID mice using a self-inactivating HIV-1-derived vector...

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PMID: 16960916
DOI: 10.1002/jgm.958

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