Article

A Gene Therapy for Hereditary Nonpolyposis Colorectal Cancer using CRISPR-Cas9 Nickase

2023-06-22

Abstract excerpt

<h4>ABSTRACT</h4> Hereditary non-polyposis colorectal cancer (HNPCC) is an inherited disorder characterized by an increased risk of developing colorectal cancer before age 50. HNPCC is predominantly caused by genetic mutations in MLH1 and MSH2, which are involved in DNA mismatch repair. Current standard practice is to perform prophylactic colectomy, resulting in debilitating aftereffects for life. Though the gene...

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Literature Corpus work: e3bf3c1b-3ae2-591e-a434-9d20b62f72c2
DOI: 10.1101/2023.06.20.545835

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