Article

The Ala134Thr variant in TMEM176B exerts a beneficial role in colorectal cancer prognosis by increasing NLRP3 inflammasome activation

2022-07-05

Abstract excerpt

<h4>Purpose: </h4> TMEM176B was recently described as a negative modulator of Nlrp3 inflammasome activation in mice. In the mouse model, the inhibition of TMEM176B leads to an increased anti-tumoral activity which is dependent on Nlrp3. Since we have recently shown that single nucleotide variants (SNPs) in inflammasome genes, including NLRP3 , significantly affect colorectal cancer (CRC) prognosis, we proposed to...

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Literature Corpus work: e3b41bd9-5522-5290-9740-9b4f650de34d
DOI: 10.21203/rs.3.rs-1782224/v1

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