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Article

The Ala134Thr variant in TMEM176B exerts a beneficial role in colorectal cancer prognosis by increasing NLRP3 inflammasome activation.

Journal of cancer research and clinical oncology - 1 Jul 2023

Cambui Raylane Adrielle Gonçalves, Fernandes Fernanda Pereira, Leal Vinicius Nunes Cordeiro, Reis Edione Cristina, de Lima Dhemerson Souza, do Espírito Santo Gilmar Ferreira, Elias Rosa Maria, Pontillo Alessandra

Abstract excerpt

PURPOSE: TMEM176B was recently described as a negative modulator of Nlrp3 inflammasome activation in mice. In the mouse model, the inhibition of TMEM176B leads to an increased anti-tumoral activity which is dependent on Nlrp3. Since we have recently shown that single nucleotide variants (SNPs) in inflammasome genes, including NLRP3, significantly affect colorectal cancer (CRC) prognosis, we proposed to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35980484
DOI: 10.1007/s00432-022-04284-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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