Article

Twinkle is not the mitochondrial DNA replicative helicase in <i>C. elegans</i> , but may have alternate mitochondrial functions

2019-02-20

Abstract excerpt

<h4>ABSTRACT</h4> Dysfunction of mitochondrial DNA replication machinery is a common cause of mitochondrial diseases. The minimal mammalian replisome is made up of DNA polymerase gamma, replicative helicase Twinkle, and single-stranded DNA binding protein. The replisome is localized to the inner mitochondrial membrane and serves as the site of mitochondrial DNA replication and mitochondrial fission. Recently, a s...

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Literature Corpus work: e3a8bdd8-df37-5d17-9661-1c7d685532d9
DOI: 10.1101/497305

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