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Article

Negative regulation of<i>ACE2</i>by interferons<i>in vivo</i>and its genetic control

2020-04-29

Abstract excerpt

The SARS-CoV-2 pandemic has resulted in widespread morbidity and mortality globally. ACE2 is a receptor for SARS-CoV-2 and differences in expression may affect susceptibility to COVID-19. Using HCV-infected liver tissue from 195 individuals, we discovered that among genes negatively correlated with ACE2 , interferon signalling pathways were highly enriched and observed down-regulation of ACE2 after interferon-alph...

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Literature Corpus work
5b5eacd4-41b8-5fe0-8037-333157428f86
DOI
10.1101/2020.04.26.20080408
Open publication

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Negative regulation of<i>ACE2</i>by interferons<i>in vivo</i>and its genetic controlDOI 10.1101/2020.04.26.20080408
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