Article

Mediator Subunit Med4 Enforces Metastatic Dormancy in Breast Cancer

2023-11-19

Abstract excerpt

<h4>Summary</h4> Long term survival of breast cancer patients is limited due to recurrence from metastatic dormant cancer cells. However, the mechanisms by which these dormant breast cancer cells survive and awaken remain poorly understood. Our unbiased genome-scale genetic screen in mice identified Med4 as a novel cancer-cell intrinsic gatekeeper in metastatic reactivation. MED4 haploinsufficiency is prevalent...

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Literature Corpus work: e38e3eac-c0fd-5d31-aace-41a7de47e350
DOI: 10.1101/2023.11.18.566087

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