Article

FairTCR: Equity-Aware TCR–pMHC Binding Prediction Across HLA Alleles and Cohort Strata

2026-04-17

Abstract excerpt

Public TCR–pMHC binding databases are heavily skewed toward a handful of well-studied HLA alleles— most prominently HLA-A*02:01, which covers ∼45% of curated records—and toward patients from European-ancestry cohorts. Standard empirical risk minimization (ERM) trained on such data achieves strong pooled accuracy but routinely underperforms on rare alleles and underrepresented cohorts, creating systematic dispariti...

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Literature Corpus work: e375656d-0124-5a2a-b28f-9a0559c7518d
DOI: 10.64898/2026.04.14.718511

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