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Article

Selection for translation efficiency on synonymous polymorphisms in recent human evolution.

Genome biology and evolution - 1 Jan 2011

Waldman Yedael Y, Tuller Tamir, Keinan Alon, Ruppin Eytan

Abstract excerpt

Synonymous mutations are considered to be "silent" as they do not affect protein sequence. However, different silent codons have different translation efficiency (TE), which raises the question to what extent such mutations are really neutral. We perform the first genome-wide study of natural selection operating on TE in recent human evolution, surveying 13,798 synonymous single nucleotide polymorphisms (SNPs) in...

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Identifiers

PMID: 21803767
DOI: 10.1093/gbe/evr076
PMCID: PMC3163469

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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