Article
In-silico predicted mouse melanopsins with blue spectral shifts deliver efficient subcellular signaling.
Cell communication and signaling : CCS - 8 Aug 2024
Wijayaratna Dhanushan, Sacchetta Filippo, Pedraza-González Laura, Fanelli Francesca, Sugihara Tomohiro, Koyanagi Mitsumasa, Piyawardana Senuri, Ghotra Kiran, Thotamune Waruna, Terakita Akihisa, Olivucci Massimo, Karunarathne Ajith
Abstract excerpt
Melanopsin is a photopigment belonging to the G Protein-Coupled Receptor (GPCR) family expressed in a subset of intrinsically photosensitive retinal ganglion cells (ipRGCs) and responsible for a variety of processes. The bistability and, thus, the possibility to function under low retinal availability would make melanopsin a powerful optogenetic tool. Here, we aim to utilize mouse melanopsin to trigger macrophage...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.