Article

Treatment with M51R Vesicular Stomatitis Virus Induces Clonal Antitumor CD8+ T Cell Expansion in Colon Cancer

2023-07-12

Abstract excerpt

Developing new and effective treatments for patients with metastatic colorectal cancer is crucial, as this condition is the fourth leading cause of cancer-related deaths. The potential of the M51R vesicular stomatitis virus (M51R VSV) as an oncolytic virus for various malignancies, including colorectal cancer, is being explored by our group and others. However, the immune response to this treatment is poorly under...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e35d30a3-0e21-5a4d-a7f1-8476591e8eab
DOI: 10.21203/rs.3.rs-3149824/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Treatment with M51R Vesicular Stomatitis Virus Induces Clonal Antitumor CD8+ T Cell Expansion in Colon CancerDOI 10.21203/rs.3.rs-3149824/v1Read

VSV strains with defects in their ability to shutdown innate immunity are potent systemic anti-cancer agents.Semantic proximity Read

Reovirus sensitizes microsatellite stable colorectal cancer to anti-PD-1 treatment via cross-talk in innate and adaptive immune systemsSemantic proximity Read

Immunovirotherapy Based on Recombinant Vesicular Stomatitis Virus: Where Are We?Semantic proximity Read

A novel vaccinia virus enhances anti-tumor efficacy and promotes a long-term anti-tumor response in a murine model of colorectal cancerSemantic proximity Read

Experimental Evolution Generates Novel Oncolytic Vesicular Stomatitis Viruses with Improved Replication in Virus-Resistant Pancreatic Cancer Cells.Semantic proximity Read

Vesicular stomatitis virus variants selectively infect and kill human melanomas but not normal melanocytes.Semantic proximity Read

A rationally designed A34R mutant oncolytic poxvirus: improved efficacy in peritoneal carcinomatosis.Semantic proximity Read

Intertumoral heterogeneity impacts oncolytic vesicular stomatitis virus efficacy in mouse pancreatic cancer cellsSemantic proximity Read

Oncolytic vesicular stomatitis virus as a treatment for neuroendocrine tumors.Semantic proximity Read

Efficacy of systemically administered mutant vesicular stomatitis virus (VSVDelta51) combined with radiation for nasopharyngeal carcinoma.Semantic proximity Read

Intravenous injection of tumor extracellular vesicles suppresses tumor growth by reducing the regulatory T cell phenotype.Semantic proximity Read

Characterization of Morreton Virus (MORV) as a Novel Oncolytic Virotherapy Platform for Liver CancersSemantic proximity Read