Article
Efficacy of systemically administered mutant vesicular stomatitis virus (VSVDelta51) combined with radiation for nasopharyngeal carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Aug 2008
Alajez Nehad M, Mocanu Joseph D, Shi Wei, Chia Marie C, Breitbach Caroline J, Hui Angela B Y, Knowles Shane, Bell John C, Busson Pierre, Takada Kenzo, Lo Kwok-Wai, O'Sullivan Brian, Gullane Pat, Liu Fei-Fei
Abstract excerpt
PURPOSE: Nasopharyngeal carcinoma (NPC) is a malignancy of the head and neck region that is associated with EBV latency. Curative treatments for NPC achieve modest survival rates, underscoring a need to develop novel therapies. We evaluated the therapeutic potential of a mutant vesicular stomatitis virus (VSVDelta51) as single treatment modality or in combination with ionizing radiation (RT) in NPC. EXPERIMENTAL...
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