Article
Characterization of Morreton Virus (MORV) as a Novel Oncolytic Virotherapy Platform for Liver Cancers
2022-03-11
Abstract excerpt
Morreton virus (MORV) is a novel oncolytic Vesiculovirus , genetically distinct from vesicular stomatitis virus (VSV). we report that MORV induced potent cytopathic effects in a panel of cholangiocarcinoma (CCA) and hepatocellular carcinoma (HCC) cell lines. In addition, high intranasal doses of MORV were not associated with significant adverse effects and were well tolerated in mice bearing liver tumor xenograft...
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Identifiers and source
- Literature Corpus work
- f3f7f0f0-5b03-5d4f-aea6-2eb1f63e403d
- DOI
- 10.1101/2022.03.10.483848