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Article

Vesicular stomatitis virus variants selectively infect and kill human melanomas but not normal melanocytes.

Journal of virology - 1 Jun 2013

Wollmann Guido, Davis John N, Bosenberg Marcus W, van den Pol Anthony N

Abstract excerpt

Metastatic malignant melanoma remains one of the most therapeutically challenging forms of cancer. Here we test replication-competent vesicular stomatitis viruses (VSV) on 19 primary human melanoma samples and compare these infections with those of normal human melanocyte control cells. Even at a low viral concentration, we found a strong susceptibility to viral oncolysis in over 70% of melanomas. In contrast,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23552414
DOI: 10.1128/JVI.03311-12
PMCID: PMC3676084

Genes

BRAF
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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