Article
Oncolytic vesicular stomatitis virus as a treatment for neuroendocrine tumors.
Surgery - 1 Dec 2013
Randle Reese W, Northrup Scott A, Sirintrapun S Joseph, Lyles Douglas S, Stewart John H
Abstract excerpt
BACKGROUND: Therapeutic goals for neuroendocrine tumors (NETs) not amenable to operative cure are limited to relieving symptoms and slowing progression. Many malignancies acquire defective antiviral responses as they undergo unregulated proliferation. Therefore, we explored the abilities of recombinant wild-type vesicular stomatitis virus and an attenuated matrix protein mutant (M51R-VSV) to exploit defective...
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