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Article

The effects of exercise on hypothalamic neurodegeneration of Alzheimer’s disease mouse model

2 Jan 2018

Abstract excerpt

Alzheimer's disease is a neurodegenerative disorder that affects the central nervous system. In this study, we characterized and examined the early metabolic changes in the triple transgenic mouse AD model (3xtg-AD), and their relationship with the hypothalamus, a key regulator of metabolism in the central nervous system. We observed that the 3xtg-AD model exhibited significantly higher oxygen consumption as well...

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PMID: 29293568
DOI: 10.1371/journal.pone.0190205

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