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Exploiting HSD17B11-dependent dialkynylcarbinols cytotoxicity for facile CRISPR/Cas9-based gene inactivation

2026-05-13

Abstract excerpt

Several approaches are available to increase the efficiency of CRISPR/Cas9-based genome editing, including the co-inactivation of a gene that mediates the cytotoxic activity of a compound which can be used to enrich the population in edited cells. Here we show in multiple cell lines how inactivating HSD17B11, a non-essential Short-chain Dehydrogenase/Reductase, confers a strong resistance (29- to 130-fold resistan...

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Literature Corpus work
e33a6de6-6ae4-50a7-9d50-07195b8bb5fd
DOI
10.64898/2026.05.13.724824
Open publication

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Exploiting HSD17B11-dependent dialkynylcarbinols cytotoxicity for facile CRISPR/Cas9-based gene inactivationDOI 10.64898/2026.05.13.724824
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