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An <i>Nlrp5</i> -null mutation leads to attenuated <i>de novo</i> methylation in oocytes, accompanied by a significant reduction in DNMT3L

2025-02-23

Abstract excerpt

Nlrp5 encodes a core component of the subcortical maternal complex (SCMC) a cytoplasmic protein structure unique to the mammalian oocyte and cleavage-stage embryo. NLRP5 mutations have been identified in patients presenting with early embryo arrest, recurrent molar pregnancies and imprinting disorders. Correct patterning of DNA methylation over imprinted domains during oogenesis is necessary for faithful imprinti...

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Literature Corpus work
e31270bf-e135-5627-9f38-90f7d48a88ef
DOI
10.1101/2025.02.20.639225
Open publication

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An <i>Nlrp5</i> -null mutation leads to attenuated <i>de novo</i> methylation in oocytes, accompanied by a significant reduction in DNMT3LDOI 10.1101/2025.02.20.639225
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