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Article

DNA Methylation Dynamics in the Female Germline and Maternal-Effect Mutations That Disrupt Genomic Imprinting.

Genes - 6 Aug 2021

Anvar Zahra, Chakchouk Imen, Demond Hannah, Sharif Momal, Kelsey Gavin, Van den Veyver Ignatia B

Abstract excerpt

Genomic imprinting is an epigenetic marking process that results in the monoallelic expression of a subset of genes. Many of these 'imprinted' genes in mice and humans are involved in embryonic and extraembryonic growth and development, and some have life-long impacts on metabolism. During mammalian development, the genome undergoes waves of (re)programming of DNA methylation and other epigenetic marks....

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Identifiers

PMID: 34440388
DOI: 10.3390/genes12081214
PMCID: PMC8394515

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