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Article

An Nlrp5-null mutation leads to attenuated de novo methylation in oocytes, accompanied by a significant reduction in DNMT3L.

Molecular human reproduction - 2 Oct 2025

Nic Aodha Leah, Pokhilko Alexandra, Rosen Leah U, Galatidou Styliani, Walewska Edyta, Belton Christian, Galvao Antonio, Okkenhaug Hanneke, Yu Lu, Nakhuda Asif, Mansfield Bill, Khan Soumen, Oxley David, Barragán Montserrat, Kelsey Gavin

Abstract excerpt

Nlrp5 encodes a core component of the subcortical maternal complex (SCMC), a cytoplasmic protein structure unique to the mammalian oocyte and cleavage-stage embryo. NLRP5 mutations have been identified in patients presenting with early embryo arrest, recurrent molar pregnancies, and imprinting disorders. Correct patterning of DNA methylation over imprinted domains during oogenesis is necessary for faithful...

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Share to DNA (Cytosine-5-)-Methyltransferases
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenesis, Genetic

Share to Genomic Imprinting

Share to Mice, Knockout

Share to Oocytes

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Source

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Identifiers

PMID: 41252458
DOI: 10.1093/molehr/gaaf055
PMCID: PMC12704423

Genes

DNMT3L
KHDC3L
NLRP5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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An Nlrp5-null mutation leads to attenuated de novo methylation in oocytes, accompanied by a significant reduction in DNMT3L.PMID 41252458Read ↗

An <i>Nlrp5</i> -null mutation leads to attenuated <i>de novo</i> methylation in oocytes, accompanied by a significant reduction in DNMT3LSemantic proximity Read ↗

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Maternal loss-of-function of Nlrp2 results in failure of epigenetic reprogramming in mouse oocytesSemantic proximity Read ↗

The maternal protein NLRP5 stabilizes UHRF1 in the cytoplasm: implication for the pathogenesis of multilocus imprinting disturbanceSemantic proximity Read ↗

Variants in NLRP2 and ZFP36L2, non-core components of the human subcortical maternal complex, cause female infertility with embryonic development arrestSemantic proximity Read ↗

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