Article

Fluorescently guided workflow with rationally engineered 5′ ligation adapters for high-sensitivity and low-bias small RNA sequencing

2026-06-24

Abstract excerpt

MicroRNAs (miRNAs) act as key regulators of gene expression across diverse cellular processes, and their precise quantification can provide unique insight into disease pathogenesis. High-throughput sequencing allows for comprehensive small RNA profiling; however, standard commercial library preparation workflows are challenged by issues of low sensitivity and representational bias, limiting reliable profiling, esp...

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Literature Corpus work: e30884c3-be43-5f29-8291-2c831ecb2b97
DOI: 10.64898/2026.06.23.733996

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