Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Negative screening for 12 rare LRRK2 pathogenic variants in a cohort of Nigerians with Parkinson's disease.

Neurobiology of aging - 1 Mar 2021

Rizig Mie, Ojo Oluwadamilola O, Athanasiou-Fragkouli Alkyoni, Agabi Osigwe P, Oshinaike Olajumoke O, Houlden Henry, Okubadejo Njideka U

Abstract excerpt

Leucine-rich repeat kinase 2 (LRRK2) gene mutations are the most common genetic cause of Parkinson's disease (PD). More than 300 rare LRRK2 variants have been described, with approximately 17 having confirmed or probable pathogenic role in PD. The distribution differs across ethnic groups, but no PD-related LRRK2 pathogenic variant has been described in persons of Black African ancestry within or outside Africa....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Black People
Share to Cohort Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Association Studies

Share to Genetic Variation

Share to Leucine-Rich Repeat Serine-Threonine Protein Kinase-2

Share to Nigeria

Share to Parkinson Disease

Source

Identifiers

PMID: 33158606
DOI: 10.1016/j.neurobiolaging.2020.09.024

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Negative screening for 12 rare LRRK2 pathogenic variants in a cohort of Nigerians with Parkinson's disease.PMID 33158606Read ↗

Negative screening for 12 rare LRRK2 pathogenic variants in a cohort of Nigerians with Parkinson’s diseaseSemantic proximity Read ↗

Leucine rich repeat kinase 2 (LRRK2) GLY2019SER mutation is absent in a second cohort of Nigerian Africans with Parkinson diseaseSemantic proximity Read ↗

Leucine rich repeat kinase 2 (LRRK2) gly2019ser mutation is absent in a second cohort of nigerian africans with parkinson diseaseSemantic proximity Read ↗

Comprehensive sequencing of the LRRK2 gene in patients with familial Parkinson's disease from North Africa.Semantic proximity Read ↗

Analysis of Nigerians with apparently sporadic Parkinson disease for mutations in LRRK2, PRKN and ATXN3.Semantic proximity Read ↗

Targeted next-generation sequencing identifies novel variants in candidate genes for Parkinson's disease in Black South African and Nigerian patients.Semantic proximity Read ↗

LRRK2 G2019S in the North African population: a review.Semantic proximity Read ↗

LRRK2 variation and Parkinson's disease in African Americans.Semantic proximity Read ↗

An overview of the worldwide distribution of LRRK2 mutations in Parkinson's disease.Semantic proximity Read ↗

Absence of commonly reported leucine-rich repeat kinase 2 mutations in Eastern Indian Parkinson's disease patients.Semantic proximity Read ↗

Molecular analyses of the LRRK2 gene in European and North African autosomal dominant Parkinson’s diseaseSemantic proximity Read ↗

G2019S LRRK2 mutation in French and North African families with Parkinson's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.