Targeted next-generation sequencing identifies novel variants in candidate genes for Parkinson's disease in Black South African and Nigerian patients.

doi:10.1186/s12881-020-0953-1

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Targeted next-generation sequencing identifies novel variants in candidate genes for Parkinson's disease in Black South African and Nigerian patients.

BMC medical genetics - 4 Feb 2020

Oluwole Oluwafemi G, Kuivaniemi Helena, Abrahams Shameemah, Haylett William L, Vorster Alvera A, van Heerden Carel J, Kenyon Colin P, Tabb David L, Fawale Michael B, Sunmonu Taofiki A, Ajose Abiodun, Olaogun Matthew O, Rossouw Anastasia C, van Hillegondsberg Ludo S, Carr Jonathan, Ross Owen A, Komolafe Morenikeji A, Tromp Gerard, Bardien Soraya

Abstract excerpt

BACKGROUND: The prevalence of Parkinson's disease (PD) is increasing in sub-Saharan Africa, but little is known about the genetics of PD in these populations. Due to their unique ancestry and diversity, sub-Saharan African populations have the potential to reveal novel insights into the pathobiology of PD. In this study, we aimed to characterise the genetic variation in known and novel PD genes in a group of...

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PMID: 32019516
DOI: 10.1186/s12881-020-0953-1
PMCID: PMC7001245

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