Article

SLC25A26-mediated SAM compartmentalization coordinates translation and bioenergetics during cardiac hypertrophy

2024-08-02

Abstract excerpt

<h4>ABSTRACT</h4> <h4>BACKGROUND</h4> The heart undergoes hypertrophy as a compensatory mechanism to cope with increased hemodynamic stress, and it can transition into a primary driver of heart failure. Pathological cardiac hypertrophy is characterized by excess protein synthesis. Protein translation is an energy-intensive process that necessitates an inherent mechanism to flexibly fine-tune intracellular bioenerg...

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Literature Corpus work: c079d6bf-5ce8-5020-b737-71b9f9825684
DOI: 10.1101/2024.07.30.24311193

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