Article

GDNF levels regulate lumbar motor neuron physiology and determine life expectancy in limb-onset ALS

2025-12-05

Abstract excerpt

Approximately one-third of amyotrophic lateral sclerosis (ALS) patients die within 12 months, while up to 10% live more than a decade. The factors driving this variation remain unclear but may elucidate disease mechanisms and guide therapy development. Here, we analyzed raw postmortem RNA-seq datasets from ALS patients and controls to quantify glial cell line-derived neurotrophic factor (GDNF) expression across ce...

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Literature Corpus work: e272e92b-8e0f-5bbd-8318-f465aec4451c
DOI: 10.64898/2025.12.05.25341683

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