Article

Saturation resistance profiling of EGFR variants against tyrosine kinase inhibitors using prime editing

2023-12-05

Abstract excerpt

Variants of uncertain significance (VUS) hamper the clinical application of genetic information. For example, in treating lung cancer with tyrosine kinase inhibitors (TKIs), many epidermal growth factor receptor (EGFR) variants remain classified as VUS with respect to TKI sensitivity 1,2 . Such incomplete resistance profiles hinder clinicians from selecting optimal therapeutic agents 3,4 . A high-throughput appr...

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Literature Corpus work: e2608c93-dd71-506e-80be-3411f41bf729
DOI: 10.1101/2023.12.03.569825

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