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Article

A comprehensive functional atlas of ALK kinase domain variants reveals resistance landscape to ALK inhibitors.

Genome biology - 3 Feb 2026

Oh Hyeong-Cheol, Han Yeonseung, Chang Yoojin, Kim Hyongbum Henry

Abstract excerpt

BACKGROUND: ALK gene fusions are key oncogenic drivers in cancers such as non-small cell lung cancer, where they define a molecular subtype responsive to ALK tyrosine kinase inhibitors (TKIs). However, resistance commonly arises due to single nucleotide variants (SNVs) within the ALK tyrosine kinase domain, many of which remain variants of uncertain significance (VUSs). RESULTS: To systematically profile...

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Identifiers

PMID: 41630044
DOI: 10.1186/s13059-026-03977-4
PMCID: PMC12958575

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ALK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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