Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A method of high-throughput functional evaluation of EGFR gene variants of unknown significance in cancer.

Science translational medicine - 15 Nov 2017

Kohsaka Shinji, Nagano Masaaki, Ueno Toshihide, Suehara Yoshiyuki, Hayashi Takuo, Shimada Naoko, Takahashi Kazuhisa, Suzuki Kenji, Takamochi Kazuya, Takahashi Fumiyuki, Mano Hiroyuki

Abstract excerpt

Numerous variants of unknown significance (VUS) have been identified through large-scale cancer genome projects, although their functional relevance remains uninvestigated. We developed a mixed-all-nominated-mutants-in-one (MANO) method to evaluate the transforming potential and drug sensitivity of oncogene VUS in a high-throughput manner and applied this method to 101 nonsynonymous epidermal growth factor...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3T3 Cells
Share to Cell Survival

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Neoplasm

Share to ErbB Receptors

Share to Erlotinib Hydrochloride

Share to Gefitinib

Share to HEK293 Cells

Share to Quinazolines

Source

Identifiers

PMID: 29141884
DOI: 10.1126/scitranslmed.aan6566

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A method of high-throughput functional evaluation of EGFR gene variants of unknown significance in cancer.PMID 29141884Read ↗

High-Throughput Functional Evaluation of Variants of Unknown Significance in ERBB2.Semantic proximity Read ↗

Saturation resistance profiling of EGFR variants against tyrosine kinase inhibitors using prime editingSemantic proximity Read ↗

Defining the sensitivity landscape of EGFR variants to tyrosine kinase inhibitors.Semantic proximity Read ↗

Functional Analysis of Rare RAS Variants of Unknown Significance.Semantic proximity Read ↗

Rare mutation-dominant compound EGFR-positive NSCLC is associated with enriched kinase domain-resided variants of uncertain significance and poor clinical outcomes.Semantic proximity Read ↗

Defining the Sensitivity Landscape of 74,389 EGFR Variants to Tyrosine Kinase InhibitorsSemantic proximity Read ↗

Discrimination of driver and passenger mutations in epidermal growth factor receptor in cancer.Semantic proximity Read ↗

Defining the Sensitivity Landscape of 74,389 EGFR Variants to Tyrosine Kinase InhibitorsSemantic proximity Read ↗

High-throughput oncogene mutation profiling in human cancer.Semantic proximity Read ↗

An unbiased in vitro screen for activating epidermal growth factor receptor mutationsSemantic proximity Read ↗

Pan-cancer inference and validation of hypermorphic, hypomorphic and neomorphic mutations.Semantic proximity Read ↗

Systematic Functional Interrogation of Rare Cancer Variants Identifies Oncogenic Alleles.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.