Article
Mutation as a stress response and the regulation of evolvability.
Critical reviews in biochemistry and molecular biology - 1 Jan 2000
Galhardo Rodrigo S, Hastings P J, Rosenberg Susan M
Abstract excerpt
Our concept of a stable genome is evolving to one in which genomes are plastic and responsive to environmental changes. Growing evidence shows that a variety of environmental stresses induce genomic instability in bacteria, yeast, and human cancer cells, generating occasional fitter mutants and potentially accelerating adaptive evolution. The emerging molecular mechanisms of stress-induced mutagenesis vary but...
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