Article

Neutrophil-derived complement factor P induces cytotoxicity in basal-like cells via caspase 3/7 activation in pancreatic cancer

2023-11-01

Abstract excerpt

<h4>ABSTRACT</h4> Due to profound heterogeneity within stromal immune tumor microenvironment (TME), pancreatic ductal adenocarcinoma (PDAC) remains a hard to treat disease, with the lowest 5-year survival below 10%. Large-scale transcriptomic analysis has revealed two main, clinically relevant PDAC signatures: therapy responsive ‘Classical’ subtype with better prognosis, and poorly-differentiated Basal-like with...

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Literature Corpus work: 027cf22c-10ee-5cba-937b-c61ad1b848fd
DOI: 10.1101/2023.10.28.564512

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