Article

An unconventional mechanism of IL-1β secretion that requires Type I IFN in lupus monocytes

2023-08-03

Abstract excerpt

Systemic Lupus Erythematosus (SLE) is characterized by autoreactive B cell activation, upregulation of Type I Interferon (IFN) and widespread inflammation. Mitochondrial nucleic acids (NAs) are increasingly recognized as triggers of IFN 1 . Thus, defective removal of mitochondria from mature red blood cells (Mito + RBCs), a feature of SLE, contributes to IFN production by myeloid cells 2 . Here we identify bloo...

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Literature Corpus work: e1d479b5-2107-576d-89fd-b3699ad38bbf
DOI: 10.1101/2023.08.03.551696

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