Article

Rett Syndrome astrocytes disrupt neuronal activity and cerebral organoid development through transfer of dysfunctional mitochondria

2023-03-02

Abstract excerpt

Studies on the function of Methyl CpG binding protein 2 (MECP2) and the consequence of MECP2 deficiency and duplication have largely focused on neurons. The function of MECP2 in human glia, along with the comprehensive understanding of glial function in neurodevelopmental disorders, is much less understood. Using female and male human embryonic stem cell (hESC) lines to model MECP2 loss-of-function (LOF) in Rett...

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Literature Corpus work: 09f1c364-5245-5b58-81dd-ab3d5f2aea00
DOI: 10.1101/2023.03.02.530903

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