Article
Cell Metabolic Alterations due to Mcph1 Mutation in Microcephaly.
Cell reports - 14 Apr 2020
Journiac Nathalie, Gilabert-Juan Javier, Cipriani Sara, Benit Paule, Liu Xiaoqian, Jacquier Sandrine, Faivre Valérie, Delahaye-Duriez Andrée, Csaba Zsolt, Hourcade Tristan, Melinte Eliza, Lebon Sophie, Violle-Poirsier Céline, Oury Jean-François, Adle-Biassette Homa, Wang Zhao-Qi, Mani Shyamala, Rustin Pierre, Gressens Pierre, Nardelli Jeannette
Abstract excerpt
A distinctive feature of neocortical development is the highly coordinated production of different progenitor cell subtypes, which are critical for ensuring adequate neurogenic outcome and the development of normal neocortical size. To further understand the mechanisms that underlie neocortical growth, we focused our studies on the microcephaly gene Mcph1, and we report here that Mcph1 (1) exerts its functions in...
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