Article

Transfer Elastic Net for Developing Epigenetic Clocks for the Japanese Population

2024-08-30

Abstract excerpt

The epigenetic clock evaluates human biological age based on DNA methylation patterns. It takes the form of a regression model where the methylation ratio at CpG sites serves as the predictor and age as the response variable. Due to the large number of CpG sites and their correlation, Elastic Net is commonly used to train the models. However, existing standard epigenetic clocks, trained on multiracial data, may ex...

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Literature Corpus work: e1c6207f-6477-56b6-86de-584aca45f22f
DOI: 10.3390/math12172716

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