Article
Weighted 2D-kernel density estimations provide a new probabilistic measure for epigenetic age
22 Apr 2025
Abstract excerpt
Epigenetic aging signatures provide insights into human aging, but traditional clocks rely on linear regression of DNA methylation levels, assuming linear trajectories. This study explores a non-parametric approach using 2D-kernel density estimation to determine epigenetic age. Our weighted model achieves similar predictive accuracy as conventional clocks and provides a variation score reflecting the inherent...
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