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Article

Peroxiredoxin-2 represses NRAS-mutated melanoma cells invasion by modulating EMT markers.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Aug 2024

Noma Isabella Harumi Yonehara, Carvalho Larissa Anastacio da Costa, Camarena Denisse Esther Mallaupoma, Silva Renaira Oliveira, Moraes Junior Manoel Oliveira de, de Souza Sophia Tavares, Newton-Bishop Julia, Nsengimana Jérémie, Maria-Engler Silvya Stuchi

Abstract excerpt

The second most common mutation in melanoma occurs in NRAS oncogene, being a more aggressive disease that has no effective approved treatment. Besides, cellular plasticity limits better outcomes of the advanced and therapy-resistant patients. Peroxiredoxins (PRDXs) control cellular processes through direct hydrogen peroxide oxidation or by redox-relaying processes. Here, we demonstrated that PRDX2 could act as a...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 38955087
DOI: 10.1016/j.biopha.2024.116953

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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