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Defective mitophagy and the etiopathogenesis of Alzheimer’s disease

3 Jun 2022

Abstract excerpt

Accumulation of impaired mitochondria and energy metabolism disorders are non-negligible features of both aging and age-related neurodegeneration, including Alzheimer's disease (AD). A growing number of studies suggest that mitophagy disorders play an important role in AD occurrence and development. The interaction between mitophagy deficits and Aβ or Tau pathology may form a vicious cycle and cause neuronal...

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PMID: 35655270
DOI: 10.1186/s40035-022-00305-1

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