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Article

Culprit or Bystander: Defective Mitophagy in Alzheimer’s Disease

17 Jan 2020

Abstract excerpt

Mitophagy is a selective engulfment and degradation of damaged mitochondria through the cellular autophagy machinery, a major mechanism responsible for mitochondrial quality control. Increased accumulation of damaged mitochondria in the Alzheimer's disease (AD) human brain are evident, although underlying mechanisms largely elusive. Recent studies indicate impaired mitophagy may contribute to the accumulation of...

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Identifiers

PMID: 32010698
DOI: 10.3389/fcell.2019.00391

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