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Article

The HDAC inhibitor trichostatin A impairs pancreatic β-cell function through an epigenome-wide reprogramming

2022-12-15

Abstract excerpt

<h4>Objective</h4> The pancreatic islets of Langerhans contain distinct cell subtypes including insulin-producing β cells. Although their cell-specific gene expression pattern defines their identity, the underlying molecular network driving this transcriptional specificity is not fully understood. Among the numerous transcriptional regulators, histone deacetylases (HDAC) enzymes are potent chromatin modifiers whi...

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Literature Corpus work
e1823c0b-15a4-5e33-a268-7c69cfb9a597
DOI
10.1101/2022.12.14.519294
Open publication

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The HDAC inhibitor trichostatin A impairs pancreatic β-cell function through an epigenome-wide reprogrammingDOI 10.1101/2022.12.14.519294
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