Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Specific Control of Pancreatic Endocrine β- and δ-Cell Mass by Class IIa Histone Deacetylases HDAC4, HDAC5, and HDAC9

28 Sept 2011

Abstract excerpt

OBJECTIVE: Class IIa histone deacetylases (HDACs) belong to a large family of enzymes involved in protein deacetylation and play a role in regulating gene expression and cell differentiation. Previously, we showed that HDAC inhibitors modify the timing and determination of pancreatic cell fate. The aim of this study was to determine the role of class IIa HDACs in pancreas development. RESEARCH DESIGN AND METHODS:...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Histone Deacetylase Inhibitors Research
Share to Pancreatic function and diabetes
Share to Signaling Pathways in Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21953612
DOI: 10.2337/db11-0440

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Specific Control of Pancreatic Endocrine β- and δ-Cell Mass by Class IIa Histone Deacetylases HDAC4, HDAC5, and HDAC9PMID 21953612Read ↗

Pharmacological HDAC inhibition impairs pancreatic β-cell function through an epigenome-wide reprogrammingSemantic proximity Read ↗

Directing cell differentiation with small-molecule histone deacetylase inhibitors: The example of promoting pancreatic endocrine cellsSemantic proximity Read ↗

The HDAC inhibitor trichostatin A impairs pancreatic β-cell function through an epigenome-wide reprogrammingSemantic proximity Read ↗

Exploring histone deacetylases in type 2 diabetes mellitus: pathophysiological insights and therapeutic avenuesSemantic proximity Read ↗

HDAC7 is overexpressed in human diabetic islets and impairs insulin secretion in rat islets and clonal beta cellsSemantic proximity Read ↗

Role of histone deacetylases in pancreas: Implications for pathogenesis and therapySemantic proximity Read ↗

Pancreas dorsal lobe agenesis and abnormal islets of Langerhans in Hlxb9-deficient mice.Semantic proximity Read ↗

Retinoic acid signaling within pancreatic endocrine progenitors regulates mouse and human β cell specificationSemantic proximity Read ↗

ARID1A loss in pancreas leads to islet developmental defect and metabolic disturbanceSemantic proximity Read ↗

HDAC11, an emerging therapeutic target for metabolic disordersSemantic proximity Read ↗

Comprehensive immunohistochemical analysis of histone deacetylases in pancreatic neuroendocrine tumors: HDAC5 as a predictor of poor clinical outcomeSemantic proximity Read ↗

Pax genes and the differentiation of hormone-producing endocrine cells in the pancreas.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.