Protein acetylation derepresses Serotonin Synthesis to potentiate Pancreatic Beta-Cell Function through HDAC1-PKA-Tph1 signaling.

doi:10.7150/thno.44459

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Protein acetylation derepresses Serotonin Synthesis to potentiate Pancreatic Beta-Cell Function through HDAC1-PKA-Tph1 signaling.

Theranostics - 1 Jan 2020

Zhang Yuqing, Wang Shushu, Zhang Linlin, Zhou Feiye, Zhu Kecheng, Zhu Qin, Liu Qianqian, Liu Yun, Jiang Lei, Ning Guang, Bi Yufang, Zhou Libin, Wang Xiao

Abstract excerpt

Rationale: Protein acetylation is tightly linked to transcriptional control and energy metabolism. However, the role of protein acetylation in islet function remains enigmatic. This study aims to determine how protein acetylation controls β-cell function and explore the underlying mechanism. Methods: The gene-expression profiles were analyzed for rat islets in response to two histone deacetylase (HDAC)...

Topics

Acetylation
Animals
Cyclic AMP-Dependent Protein Kinases
Energy Metabolism
Histone Deacetylase 1
Histone Deacetylase Inhibitors
Insulin
Insulin-Secreting Cells
Male
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Knockout

Models, Animal

Mutation

Protein Processing, Post-Translational

Rats

Rats, Transgenic

Serotonin

Transcriptional Activation

Source

Open in PubMed Open full text

Identifiers

PMID: 32641996
DOI: 10.7150/thno.44459
PMCID: PMC7330849

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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