Article

Polyamine Depletion by D, L-alpha-difluoromethylornithine Inhibits Ewing Sarcoma Metastasis by Inducing Ferroptosis

2024-06-17

Abstract excerpt

<h4> A bstract </h4> Polyamine metabolism and signaling play important roles in multiple cancers but have not previously been studied in Ewing sarcoma. Here, we show that blocking polyamine synthesis with D, L-alpha-difluoromethylornithine (DFMO) causes a G1 cell cycle arrest, dose-dependent decreases in sarcosphere formation from Ewing sarcoma cell lines growing in non-adherent conditions and a decrease in clo...

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Literature Corpus work: 09d7c3bb-fee2-5041-afb5-52b1d3b3ffec
DOI: 10.1101/2024.06.14.599064

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