Article

Alveolar Type II Cell-derived MMP1 <sup>high</sup> basal cells promote destructive microcysts in idiopathic pulmonary fibrosis

2025-12-11

Abstract excerpt

Idiopathic Pulmonary Fibrosis (IPF) is a fatal lung disease characterized by progressive epithelial metaplasia and widespread fibrosis. Alveolar microcysts develop near terminal airways in IPF and are linked to poor outcome. Using HTII-280 as a short-term lineage marker of AT2-derived AT0 (SFTPC + /SCGB3A2 + ) and basaloid (KRT17⁺) cells, together with organoids and spatial transcriptomics (Xenium), we highlight...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e1777eb1-0a14-5895-90ef-ec4fe37d2c6c
DOI: 10.64898/2025.12.08.693033

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Alveolar Type II Cell-derived MMP1 <sup>high</sup> basal cells promote destructive microcysts in idiopathic pulmonary fibrosisDOI 10.64898/2025.12.08.693033Read

Characteristics of ectopic alveolar basal cells relative to airway basal cells in fibrosisSemantic proximity Read

Airway Basal Cells show a dedifferentiated KRT17 <sup>high</sup> Phenotype and promote Fibrosis in Idiopathic Pulmonary FibrosisSemantic proximity Read

Alveolar niche disruption and aberrant epithelial reprogramming are early hallmarks of idiopathic pulmonary fibrosisSemantic proximity Read

Impact of Transcriptomics on Our Understanding of Pulmonary FibrosisSemantic proximity Read

Resolving the molecular niche of pulmonary fibrosis using cryopreserved human precision cut lung slicesSemantic proximity Read

Spatial transcriptomic characterization of pathologic niches in IPFSemantic proximity Read

Identification a novel subset of alveolar type 2 cells expanding following pneumonectomy and enriched in PD-L1Semantic proximity Read

Airway basal cells show a dedifferentiated KRT17highPhenotype and promote fibrosis in idiopathic pulmonary fibrosis.Semantic proximity Read

Epigenetic de-repression of basal cell metaplasia in aging AT2 cells is a risk factor for idiopathic pulmonary fibrosis (IPF)Semantic proximity Read

In vitro culture of aberrant basal-like cells from fibrotic lung tissueSemantic proximity Read

Spatial multiomic profiling reveals distinct fibrotic epithelial niches in idiopathic pulmonary fibrosisSemantic proximity Read

Alveolar epithelial cells are competent producers of interstitial extracellular matrix with disease relevant plasticity in a human in vitro 3D modelSemantic proximity Read