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Article

Prediction and Evolution of the Molecular Fitness of SARS-CoV-2 Variants: Introducing SpikePro.

Viruses - 18 May 2021

Pucci Fabrizio, Rooman Marianne

Abstract excerpt

The understanding of the molecular mechanisms driving the fitness of the SARS-CoV-2 virus and its mutational evolution is still a critical issue. We built a simplified computational model, called SpikePro, to predict the SARS-CoV-2 fitness from the amino acid sequence and structure of the spike protein. It contains three contributions: the inter-human transmissibility of the virus predicted from the stability of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34070055
DOI: 10.3390/v13050935
PMCID: PMC8158131

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