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Article

Insulin signaling and mitochondrial phenotype of skeletal muscle are programmed in utero by maternal diabetes.

Molecular and cellular endocrinology - 1 Jul 2024

Klöppel Eduardo, Cruz Larissa L, Prado-Souza Laura F L, Eckhardt Adam, Corrente José E, Dos Santos Daniela C, Justulin Luís A, Rodrigues Tiago, Volpato Gustavo T, Damasceno Débora C

Abstract excerpt

Maternal diabetes may influence glucose metabolism in adult offspring, an area with limited research on underlying mechanisms. Our study explored the impact of maternal hyperglycemia during pregnancy on insulin resistance development. Adult female Sprague-Dawley rats from control and diabetic mothers were mated, and their female offspring were monitored for 150 days. The rats were euthanized for blood and muscle...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Prenatal Exposure Delayed Effects

Share to Rats, Sprague-Dawley

Source

Identifiers

PMID: 38552944
DOI: 10.1016/j.mce.2024.112199

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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